AOD-9604

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AOD-9604 is a synthetic peptide and modified fragment of hGH, specifically the C-terminal region (amino acids 177-191). It was developed with the intention of mimicking the fat-burning properties of hGH without its muscle-building effects, which are not always desired in the context of weight loss.
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How AOD-9604 Works

AOD-9604 stimulates the pituitary gland, similar to how natural growth hormones regulate fat metabolism. It activates lipolysis, the breakdown of fats, and inhibits lipogenesis, the formation of fats. The peptide has been shown to reduce body weight in animal studies and in some human trials.

AOD-9604 and Metabolic Health

Research has shown that AOD-9604 can influence lipid metabolism in several ways. It has been observed to increase lipolysis, which is the breakdown of fat, and reduce lipogenesis, the process of transforming non-fat food materials into body fat.

These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604’s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis.

AOD-9604 and Weight Loss

Research has shown that AOD-9604 can stimulate lipolysis—the breakdown of fat—and inhibit lipogenesis, the transformation of non-fat food materials into body fat. In animal studies, AOD-9604 has been found to reduce body weight without significantly affecting blood sugar levels, which is a common side effect of other weight loss drugs.

Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group.

AOD-9604 and Metabolic Health

Research has shown that AOD-9604 can influence lipid metabolism in several ways. It has been observed to increase lipolysis, which is the breakdown of fat, and reduce lipogenesis, the process of transforming non-fat food materials into body fat.

These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604’s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis.

What are the Benefits of AOD9604 for Fat Loss?

Clinical studies have supported the use of AOD-9604 for weight loss in animal subjects, and while some human trials have shown promising results for fat burning, the extent of its effectiveness can vary among individuals.

  • AOD-9604 has been shown to stimulate the breakdown of fat (lipolysis) and inhibit the formation of new fat (lipogenesis), particularly in areas with high fat concentration like the stomach and thighs [[R].
  • In genetically obese Zucker rats and ob/ob mice, AOD-9604 reduced body weight without affecting glycemic control, unlike growth hormone.
  • A 12-week clinical trial showed subjects taking AOD-9604 (1 mg/d) lost an average of 2.6 kg, compared to 0.8 kg in the placebo group.